Annual changes in pulmonary function in combined pulmonary fibrosis and emphysema: Over a 5-year follow-up

Background: Combined pulmonary fibrosis and emphysema (CPFE) is a unique disorder that has been previously described, and the distinct features of CPFE in comparison with chronic obstructive pulmonary disease (COPD) have been reported. However, the yearly dynamics of pulmonary function parameters in CPFE patients compared with those in COPD patients have not yet been reported. Methods: We retrospectively enrolled patients with CPFE and COPD who had undergone pulmonary function tests more than five times during a follow-up period of more than five years. The baseline clinical characteristics and the annual changes in pulmonary function during the follow-up period in 16 stable CPFE patients were compared with those in 19 stable COPD patients. Annual changes in pulmonary function were estimated from linear regressions, with assumptions for time-dependency and linearity. We analyzed the time-dependent fluctuations in pulmonary function for the two disorders. Results: Annual decreases in VC and FVC in the CPFE group were significantly higher than those in the COPD group. Annual decrease in FEV1/FVC in the COPD group was significantly higher than in the CPFE group. During the follow-up period, FEV1/FVC in the CPFE group appeared to improve because of annual decrease in FVC. Annual decreases in DLco and DLco/VA in the CPFE group were significantly higher than those in the COPD group. Conclusion: This is the first report showing the yearly dynamics of pulmonary function parameters in CPFE patients compared with those in COPD patients during a follow-up period of more than five years. This study revealed that the physiologic consequences of CPFE including the rate of progression of pulmonary function impairment were different from those of COPD. (C) 2013 Elsevier Ltd. All rights reserved.ArticleRESPIRATORY MEDICINE. 107(12):1986-1992 (2013)journal articl

Active gas features in three HSC-SSP CAMIRA clusters revealed by high angular resolution analysis of MUSTANG-2 SZE and XXL X-ray observations

International audienceWe present results from simultaneous modelling of high angular resolution GBT/MUSTANG-2 90 GHz Sunyaev–Zel’dovich effect (SZE) measurements and XMM-XXL X-ray images of three rich galaxy clusters selected from the HSC-SSP Survey. The combination of high angular resolution SZE and X-ray imaging enables a spatially resolved multicomponent analysis, which is crucial to understand complex distributions of cluster gas properties. The targeted clusters have similar optical richnesses and redshifts, but exhibit different dynamical states in their member galaxy distributions: a single-peaked cluster, a double-peaked cluster, and a cluster belonging to a supercluster. A large-scale residual pattern in both regular Compton-parameter y and X-ray surface brightness distributions is found in the single-peaked cluster, indicating a sloshing mode. The double-peaked cluster shows an X-ray remnant cool core between two SZE peaks associated with galaxy concentrations. The temperatures of the two peaks reach ∼20–30 keV in contrast to the cool core component of ∼2 keV, indicating a violent merger. The main SZE signal for the supercluster is elongated along a direction perpendicular to the major axis of the X-ray core, suggesting a minor merger before core passage. The and y distributions are thus perturbed at some level, regardless of the optical properties. We find that the integrated Compton y parameter and the temperature for the major merger are boosted from those expected by the weak-lensing mass and those for the other two clusters show no significant deviations, which is consistent with predictions of numerical simulations

Operational experience of a 500 kV photoemission gun

Operational experience of a 500 kV photoemission gun at the compact energy recovery linac (cERL) of the High Energy Accelerator Research Organization is presented. The gun, developed at the Japan Atomic Energy Agency, was found to have failures in two out of the ten-segment ceramic insulator just after installation at cERL. The gun had been operated at 390 kV with eight segments until April 2015 and provided a 0.9 mA beam. An additional two-segment insulator was installed on the top of the existing insulators to recover the high-voltage performance. The gun was then conditioned up to 539 kV and has been operated stably at 500 kV. No discharge caused by the gun itself was observed at 500 kV once the high threshold voltage for stable operation exceeded 500 kV. A dark current of a few picoamperes was generated at 500 kV from a photocathode puck with a semiconducting wafer, while no dark current was observed without a semiconducting wafer. Stable generation of a 500 keV beam with current greater than 0.8 mA was demonstrated for more than two hours

Oprational experience of a 500 kV photoemission gun

Operational experience of a 500 kV photoemission gun at the compact energy recovery linac (cERL) of the High Energy Accelerator Research Organization is presented. The gun, developed at the Japan Atomic Energy Agency, was found to have failures in two out of the ten-segment ceramic insulator just after installation at cERL. The gun had been operated at 390 kV with eight segments until April 2015 and provided a 0.9 mA beam. An additional two-segment insulator was installed on the top of the existing insulators to recover the high-voltage performance. The gun was then conditioned up to 539 kV and has been operated stably at 500 kV. No discharge caused by the gun itself was observed at 500 kVonce the high threshold voltage for stable operation exceeded 500 kV. A dark current of a few picoamperes was generated at 500 kV from a photocathode puck with a semiconducting wafer, while no dark current was observed without a semiconducting wafer. Stable generation of a 500 keV beam with current greater than 0.8 mA was demonstrated for more than two hours

DC Photoemission Gun Upgrade at the Compact ERL

The DC photoemission gun at the compact ERL (cERL) has stably provided beam for ERL commissioning and laser Compton scattering experiments since April 2013. The operational voltage has however been limited to 390 kV due to failures of two segments out of the ten segmented insulator. In order to recover 500 kV operation, we installed an additional two segmented insulator on the existing ten segmented insulator during summer shutdown in 2015. The details of the gun upgrade and the operational experience of the upgraded cERL gun will be presented.The 7th International Particle Accelerator Conference (IPAC2016